New research reveals that patients who stop using popular slimming jabs like Mounjaro or Wegovy tend to recover lost weight far faster than those who stop conventional lifestyle plans.
Published data in a major medical journal points out that while overweight people frequently drop about a fifth of their total mass while on the medication, the weight is regained at an average rate of 0.8 kg per month upon discontinuation.
"Users purchasing these drugs should be cognizant of the risk of fast weight regain when the therapy ends," stated expert Dr. Susan Jebb.
Such speed of recovery means a return to pre-treatment weight within about 18 months.
Analyzing Treatments
The study, which examined 37 of studies involving over 9,000 of participants, contrasted the results of GLP-1 agonists with older methods.
Researchers emphasize that individuals who lose weight through dieting usually experience a less rapid weight regain—around 100 grams monthly—post-intervention.
Explaining the Fast Rebound
Nutrition scientists believe the way of the drugs is key to understanding the heightened weight return.
The injections imitate a natural hormone called GLP-1, which helps regulate hunger.
"Sustained high doses of GLP-1 levels far above than the body's typical production may cause the body to produce less of its endogenous GLP-1, and may also reduce responsiveness to its actions," explained Dr. Adam Collins, a nutrition specialist.
"Stopping of this medication results in appetite is no longer kept in check, making excessive eating far more likely."
A Chronic Issue?
The NHS advise the jabs for individuals with obesity-related medical conditions, alongside prescribed diet and exercise modifications.
A number of clinicians argue that, considering the significant potential of weight regain, the treatment should be considered long-term.
This opinion is reinforced by drug manufacturers, who note that the findings "emphasize the long-term character of obesity," similar to managing diseases like diabetes.
Patient Testimonies
Users who have discontinued the jabs explain a intense return of appetite.
"It felt as if something flipping and I was suddenly extremely hungry," described an individual.
This challenge is compounded if individuals have not adopted lasting dietary or behavioural modifications during therapy.
Significant Interest
Recent estimates indicate that a significant number of adults in the UK have tried weight-loss jabs in the last 12 months, with interest continuing to grow.
- Use is greater among females than males.
- The middle-aged age group shows the greatest usage rates.
- Many access the medications through private prescriptions rather than the NHS.
Ultimately, experts stress that while these medications are effective tools for weight loss, they are not a standalone cure and lasting health benefits likely depends on integrated behavioural management.
